Someone who cannot make any friends no matter how hard they try, works a dead-end job making less than $20k a year, lives with his parents past the age of 25, is fugly, fat, unattractive, emotionally immature, and mostly likely somewhere on the spectrum.
At the ten-year high school reunion, George (who was always a loner with no friends back in the day), was the only classmate to show-up stag. At 29, he still worked at a dead-end job making peanuts, still lived with his parents, 200 pounds overweight, face looking ugly as ever, had zero friends, and was an extreme loser.