The effect of consuming a combination of alcohol and at least one other substance (most commonly marijuana, although prescription pain medication may be used as a substitute if you have exhausted your weed supply) Common symptoms that you are twasted are slurred speech, heightened emotional state, repeatedly stating in a high pitched voice that you are "Twasted!". No future recollection of the event. Embarrassing photos soon follow.
Ooh big daddy I'm so twasted right now.
10👍 5👎