(noun) Taste or style, in reference to one's preferred musical genres, or what one likes to jam to.
Clyde: "Hey, Megadeth is coming to town! You wanna go?"
Travis: "Nah, thrash isn't my jam."
(noun) Contraction of "dopaminergenic," used as slang among drug users initially to refer to compounds stimulating the release of dopamine from cortical neurons, or inhibition of their reuptake from synaptic interstices, such as cocaine, amphetamine and their analogs. The term's use has been extended more generally to include any euphoria-inducing compound (opioids, cannabis, etc.) although the term's use as a referent to those families of drugs has varied over time, as it has with regional popularity and availability.
Cuz: "I'm not getting much of a hit off of this shit I picked up from D."
Unc: "Did you put in new Chore?"
Cuz: "Yup."
Unc: "Then it's your dope."