To be seriously fucked, fucked over. Is more commonly said as "effed in the B".
Specifically, it means to be fucked in an almost conical way which is almost funny, or to be fucked more than usual.
Jimmy: Damn, 2020 sucks
Arnold: yeah, we were really fucked in the bitch this year.
Dave: my rent is so damn high
Bob: I heard the raised it
Dave: motherfuck
Bob: I'm screwing around
Dave: eff you in the B.
I had a hard time on level 15, the boss really fucked me in the bitch