Bruce is slang for Marijuana (weed). It is a shorter version of "Bruce Banner" which is used as slang for the drug since it is the name of The Incredible Hulk who is big and green.
The most credited reference is from a rap lyric in Dr Dre's "Some L.A. Niggaz" from King T's verse which goes:
"I'm comin 'Straight Outta Compton' with a loose cannon
Smoke big green, call it Bruce Banner"
Hey man, I'm about to go out back and talk to Bruce.
Anyone seen Bruce around?
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