When you cum so hard that your balls start to hurt in agitating pain. Usually from the result of LOTS of cum.
*cums* OOWW.. literally i have PurpleBalls
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When you're so sad, you turn to comedy to feel some sort of happiness. In this case, Depressed Cheese can be some sort of flavor to your saddening comfort.
"I'm the big Depressed Cheese today boys" ;(