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It is when you are so tired, drunk, or drugged, that you brain no longer works or filter out thought. You say whatever you think. No one knows what you are talking about, because your thoughts have no focus.
"Dude, what are you talking about. You must have drunk brain. Go sleep it off."
It is when you are so tired or drunk that you don't know what you are talking about and you are slurring your words.
Me: "You should take your shirt off, because you got too much pot on it."
Dude:"You should go to bed, because you got drunk mouth. And no one knows what you are talking about."