Lame, snooty, pretentious, show-off, over-paid, nerdy tech employees living in San Francisco. Usually employed by tech companies like Twitter or they just spend time in a dorm/hack house in South of Market starting another you've-never-heard-of company.
Person 1: "Hey man, lets go to this bar in SoMa, its a chill spot! "
Me: "No, thanks. I dont wanna be seeing anymore Twitterholes, I've had enough for today. "