Take the L

When you take your first love for granted up until the point that she cheats on you, hides it from you, and leaves you, never to return, leaving you with true heartbreak and nothing but regret, because you know you *fucked* up....

Jack: I made a big mistake, man... I didn't appreciate her enough and she blocked all forms of contact. She dumped me, man... I can't believe how much of a fuck-up loser I am. I feel like I'm living in a nightmare.

Stephen: That's terrible, dude. I've been there. But you know what? Sometimes in life, you just gotta take the L. Sorry to say it.

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bicep cancer

The sort of feeling you get when you are either done wrong by a lightweight (utter loser), in numbskull fashion, rendering them an even bigger lightweight than they already were.

Guy 1: "Man that dude really did Katherine dirty the other day by spilling her egg burger all over the ground!"
Guy 2: "Yeah people like him really give me bicep cancer..."