Fucking someone in the ass while they pour spicy salsa down your urethra
Salsa is referring to the salsa down the urethra and Shake to the butt fucking
Jeffrey : You wanna set up a Salsa & Shake someday?
Frank : sure, but who's getting the salsa and who's getting shooken?
Jeffrey : I'll take salsa!
Frank : sure! But we need to find some good spicy Salsa!