The abbreviation MSF stands for "Male seeking female." This useful shorthand is used by online chat-room dwellers at random chat websites such as Omegle often in place of a greeting. By messaging MSF one clearly states to the other chatters they are a male interested in females. A female may also use the similar abbreviation FSM, or "Female seeking Male."
Stranger 1: hey MSF
Stranger 2: No way, FSM!
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