Used to describe an action that is perceived as comically undesirable.
Example 1)
Lauren: I accidentally kissed my date on the neck! He was leaning in, so I was in route for a kiss, but apparently he was going for a hug.
Amie: Ewe Laura! You're sick!
Example 2)
Pagina: (Trips and falls, stands up to try to brush it off and does an awkward jig in the process. Doesn't think anyone sees her)
Laurita: Siiick!
Pagina: Chuckles to herself.