When a character from a manga, anime, or other form of popular media breaks up with his/her lover for no apparent reason, often multiple times in a short period of time. The character with this alledged Yuki Syndrome is often of a cold and/or ass-ish personality.
Shuichi: "Hirooooo! Yuki broke up with me for the fiftieth time this week!!"
Hiro: "It's only Tuesday! He must have Yuki Syndrome."