Used as a replacement for any word meaning "very." Similar slang words are "uber," "hella," "super," etc.. Popularity originates from the phrase "so zetta slow," often used by Sho Minamimoto from Square Enix's Nintendo DS roleplaying game, the World Ends With You.
"So zetta slow!" - Sho Minamimoto, from the World Ends With You.
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