POOF

P.O.O.F.

Stands for:

People
Obviously
Over
Fucking

aka a whore or a slut.

Guy 1: Dude those chicks are hot! Totally want to hit that
Guy 2: Bad idea, man. They're obviously POOFs.
Guy 1: What the heck is a POOF?
Guy 2: Ya know... People Obviously Over Fucking.. like a whore or a slut..

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