This phrase often refers to someone who is a rude, obnoxious or has done something horrible to a person or many people. This is calling them work which we often do not like doing and calling them nasty at the same time, therefore a nasty peice of something we hate.
"That teenager has beaten up so many people for no good reason, gosh he is a NASTY PEICE OF WORK!"
This phrase is often used in first person, for e.g Is a nasty peice of work, not often Was a nasty peice of work.
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The term depressie is an abbreviated way of saying depressed. It makes it easier to say it in a sentence.
"Hello James, how are you today" "I am feeling a little depressie."
"The fortnite tryhards must be pretty depressie."
Can be used in first, second or third person.