When you get screwed over so badly it causes a massive inconvenience to your plans. Often happens in situations where you are taken advantage of in a greasy way, one where no prepareration could have been made to prevent this.
Friend 1: "I can't hang out this weekend, my boss told me to come in on Saturday AND to pay him back from the client lunch from last week."
Friend 2: "I thought he just gave you a promotion?! Sounds like you got screwed Italian Style."