DDD very clearly stands for Double-D Deprivation. This is an extremely common, and quite serious condition, in which one has not seen, let alone come into contact with, a large set of breasts in a very long time.
Possible known side effects include twitching of the eyes, seizures and prolonged periods of shameful masturbation.
John: "What's wrong with Sam? His left eye was twitching during science class and then he went into convulsions."
George: "Word on the street is that he has DDD. It's pretty serious."
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To masturbate aggressively with no intention of stopping.
Greg: "What are you up to this weekend?"
Rodney: "Nothing much. Probably just gonna sip a bottle of whiskey and hammer on my jimmy."