When a nearly-flawless male character in any form of media (usually a well-liked character or even the fanbase favorite) has a sudden change in personality as a result of a relationship with a female character. This change in personality is "a turn for the worse," making the character unwelcome in the media, and often unliked by the majority of fans.
"I don't get it! Hiro's acting like such a dick just because of that bitch Ayaka!"
"Oh, it's because of Hiro Syndrome."
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