Stfu means SHUT THE FUCK UP, it is usually used when someone say something dumb as hell and they need to be told to shut the fuck up.
Jimmy: You're gonna suck this big, fat dick till I cum.
Ashley: STFU not today
Jennifer: I'm going shopping wanna come with me?
Julie:I would but I have to vajay-ja shave today
Jennifer:oh shit, I'mma pray for you