A person held in low regard.
A person who is worthless.
Variant of dumb fuck or little fuck (guppies are little) or just plain fuck used as a noun.
Possibly of jail or penetentiary origin from the Eastern United States.
That little "guppy fuck" don't know nothin'.
Wait till I catch that little "guppy fuck" alone...
That guppy fuck of a doctor won't give me any drugs!
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