Originally from "Lose Yourself" by Eminem. "Mom's spaghetti" is used at the end of a long speech or explanation.
Steve: "We need to grow as people in order to truly grow as a society. From time and time again, we have failed to provide the basic needs to human beings and because so, there are many that die preventable deaths. One day we will outgrow this trend and become truly divine creatures; mom's spaghetti."
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When someone goes to school with a contagious disease (such as ebola, the flu, pink eye, etc.) and proceeds to spread to everyone they can.
Person 1: "Dude, Jack came to school today with ebola, started coughing on people, and got sent home before the first bell. The guy was totally plotting ebolanbine."
Person 2: "Well hopefully it won't happen again!"