You're hosed

"You're hosed." = "You're sh*t out of luck."
You are now in a hopeless position, with no known ways of escape or solution.
A polite way of saying "You have no hope."

"Hey Nick, my mother in law is coming to town next week. Any chance that one of your family members have died or something? Is there a funeral going on? I am really not trying to see her."
"Sorry John, unfortunately for you - no one has died. Looks like you're hosed."

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