Updog

The set up to a joke; when one asks what it is, it sounds like, "What's Up Dog" to which you reply, "Not Much, You?" Or something like that. The joke became wildly popular due to it's use in a 2006 episode of The Office called, "The Secret".

Hey, did you hear about that updog poisoning in New Mexico?

What's Updog?

Not much, you?