Plaster fucked

someone who is definitely drunk and/or completely under the influence of one or more drugs beyond the point of comprehension, rationality and all response. They have already met their limit and know they have met their limit but will not stop. They are definitely puking everywhere and are behaving abnormally, influenced by whatever's in their body. They must not let their heart rate get low or they’re at risk of their body shutting down completely.

The other day my friend got so plaster fucked with multiple drugs that he was at the verge of shutting down completely and dying.