A reference to the site tumblr.
A tumblrweed is a post on someone's blog that gets no likes, views, or any recognition atall.
For example, a 'supposed-to-be-funny' post that gets no laughs.
Guy 1: "Did you see that photo Dwayne put on tumblr last night?"
Guy 2: "Yeah, what a total tumblrweed."
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