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the polar opposite of a pickmeisha girl. a total, snobbish, stuck up bitch. named after Regina George of Mean Girls
Girl 1: calls bullshit on another woman*
Girl 2: OMG sis did he â¨pick youâ¨??
Girl 3: what a pickmeisha!
Girl: shut the fuck up Regina
A close friend, maybe even a best friend. Used in Urban Communities, particularly black communities (see: Harlem , South Central LA, Inglewood, Atlanta, Detroit)