A well-known insult in the Japanese manga and anime world, used on people who wear glasses. The meaning 'Four-eyes' probably came from the two physical eyes the person has, while two more eyes seen on the glasses (one eye on each glass), which makes 'four eyes' in total.
Person 1: Oi, four eyes! Get me melon bread!
Person 2: I-I didn't get my allowance today...
Person 1: *kicks Person 2 in the gut* Hah?! Who do you think you are?
Person 2: *screams in agony * F-four eyes!!
Person 3: *smashes Person 1 with an uppercut*
Person 1: *K.O*
Person 3: Hey Person 2, you alright?
Person 2: *snot and waterworks flowing* T-thank y-you so much, Person 3! Thank you!