Stands for "net option pricing effect". NOPE is a stock trading theoretical model that estimates the performance of a stock's price using historical pricing data and deep learning. It is a popular tool used for earnings season as it is very accurate in picking the wrong direction of a stock's price movement after the company releases their earnings report.
Girl: "INTC NOPE pre-earnings estimate: Right now preliminary bullish (+3.45 sigma) but let's see!"
Boy: "Time to NOPE this and load the boat with puts!"