To completely screw something up;
To destroy or masacre;
To make something that would be otherwise good, absolutely unbearable;
To completely 'fuck up' something;
Can be synonymus with: annihilate, decimate, murder, slaughhter, butcher, ruin, wreck, oblitherate, etc.
"Dude, they totally m squared that play."
"Man, did you see that chick's face - it looked so m squared."