wig out

To suddenly become unnecessarily worried, anxious, upset, or paranoid most often while under the influence of an intoxicating substance--especially marijuana.

Sometimes refers to a more favorable drug-induced mood change such as suddenly experiencing uncontrollable laughter, though the term "geek out" is more appropriate in this case.

It sucks when people wig out. Smoking in the park was awesome until Chris wigged out and made us leave. It's not like the cops would have seen us. He was just being paranoid.

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