To perform a drug transaction where you make money, free drugs, or both. It usually involves someone who does not have direct access to the a plug. The "lick" is the person who needs to go through someone else for the drugs which are usually marked up considerably by the middle man.
Yo I gotta go hit a lick on the way to McDonald's.
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The shake at the bottom of a bag of drugs, including the seeds and stems in a bag of weed. Commonly used to describe the shake at the bottom of a bag of crystal meth.
Jeff: Hey, let me get a ball of that fire ice. Dan: All I have left is the duff, bro.