When you're interested in taking your friendly relations with a girl to the next level and she rejects you, with her reason being you are like an older or younger brother figure for her. Basically a dead end to any further advances.
Guy: "So I was wondering if you'd like to go out on a real date with me sometime..."
Girl: "Ha ha no, that would be too weird! You're like a brother to me!"
Guy: "Brother zone! See ya."
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