Mainly used in Philadelphia, A Tweaker is a female who gets around! A whore, smut, slut, hoe, or trick. "Tweak" can also be used in it's place, as well as "Tweaking"
Yo bul?
"Wassup with you bul?"
Shit!...whats up with Kaneisha and them?
"I don't know.....but I def heard her squad is some tweakers!"
Oh yea?.....they tweakin?
"That's What I Heard!"
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