1. Tireless; relentlessly working; unconquerable
2. A funny word that if said fast enough can be pronounced "in - de - faggot - a - ble". Proper use denotes saying this word to closet homosexuals repeatedly until they catch on.
Person A (straight male) - "Dude, Jerry you're so indefatigable working on that roofing."
Person B (closet homo)- "Yeah man thanks!"
Person A - "You're amazingly inde-faggot-able."
Person B- "I'm beginning to take offense!"
Person A- "Faggot."
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