To have sexual intercourse, specifically penile penetration of a soft tissue orafice. Originated with the internet slang term p33n and worked its way into speech through overuse by internet geeks.
"...I walk in and she's getting peeninated by six guys from the football team!"
To defeat your opponent or otherwise humiliate him/her. Can also be used in reference to sexual dominance. Originated with the internet slang term "r0x0r".
"John can't play pool for shit. I roxorated that punk bitch."