It means really or seriously depending on however the sentence goes but either makes sense. A term created & used in New Orleans, LA. Usually used in situations in which the person is laughing. Pronounced ~ two twenty two
Johnny: "what is green, slimy, and smells like pork?"
Laura: "what?"
Johnny: "Kermit the Frog's finger!"
Laura: "I'm 222 dead!!"
15👍 19👎