Derangement Syndrome

The condition of feeling an emotion usually hate or anger so intense or irrational, at a specific person, group, or ideology, that a response is triggered which is equally intense and usually irrational.

Person 1: That dude is yelling about how x is evil incarnate. What's up with him?
Person 2: Must have x Derangement Syndrome/Must be deranged/Must have derangement syndrome.