An affirmative, used to agree to something, show interest in something, or react to something strange or awkward.
Rebecca: Jon has been such a jerk lately.
Amy: Oh, true.
Joe: I'm about to hit up karaoke with the crew, wanna come?
Matt: Oh, true? I'll see if I can.
Matt: What happened to you yesterday?
Rebecca: Well, I went to Joe's house but when I knocked on the door, his brother answered and said Joe had just left to go get food. I was like, 'Oh, TRUE?' So I stood by my car awkwardly waiting for him to get back for like twenty minutes.
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