1. Humanity's greatest creation.
2. Humanity's greatest solution.
We can sel dis nuke for a shiet ton'a dough, howbowdah?
Implied to represent something good which you or someone else has done or something you are proud of. The word derives from the game "Call of duty: Modern Warfare 2" as the best achievement one could achieve, is to get a nuke.
Verb: To destroy through the use of nuclear weapons, or to otherwise destroy figuratively. Prior to 1975, used only as a noun, until coined by me during a game of William's "Defender," at a MD video arcade.
Nuke `em!