Used often in a "No Shit" kinda way, comes from a picture of a snow owl who had a look on his face that the photographer said looked like he was saying "O RLY?"
George Bush: The Iraqi's have weapons of mass destruction.
Owl: O RLY?
Granny panty that has a hole cut out of the crotch area, often for leisure purposes.
When Anna opened her mother's dresser drawer and found a granny-o, she was shocked and embarassed.
lead singer of the new york punk band the Yeah Yeah Yeahs. Probably the coolest women on the planet-known for performing weird sexual acts with the microphone when performing live, and dressing up in ridiculous costumes, and drinking loads of booze.
guy 1: hey, did you see karen o at that concert last night
guy 2: No, why?
guy 1: because she got completely wasted and fell off the stage.
Abbrevation of orange juice
That's tasty o. j.
Can I have some more o. j.
Person 1: "Yo what happened to O To The Sev?"
Person 2 "Edot smoked with the opps, that ended their alliance"
A jiggle-o is a male prostitute
Guy 1: how did you get all this money?
Guy 2: I'm a jiggle-o
Guy 1: duuuude nice