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Term used to describe someone who is excessively ugly. If the ugliness is beyond compare use Backflip Upside Down Syndrome
John - "Yo, check out that guy over there!"
Jane - "Man, he looks like he has upside down syndrome."
Jen - "Yeah! That girl looks like she has backflip upside down syndrome!"
John - "Harsh."
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A dick that is malformed or incorrectly functions during intercourse
"I had the worst sex ever! He had Down syndrome dick!"
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thumbs down syndrome is a sickness were stupid people like to thumbs down anything and everything if they dont like what they see or read usually a response to internet videos or comments like on youtube that they dont like just to try and prove a point
bob damn bill im not feelin so good i think after readin that latest comment im coming down with thumbs down syndrome it makes me wanna go and lowrate everything that i disagree with maybe that will make me feel better about myself
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A retarded person with a screwed up face
U look like u have Down syndrome stupid fucker
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Deleted scene from family guy season 6
Fat little Nazi man with red hair and down syndrome talking about how perfect he is.
The Jews are using the blacks as muscle against the white race, WE ARE THE PERFECT RACE!!!!--Nazi with Down Syndrome
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When you are so drunk that you are killing everyones high or buzz and therefore must be choked out with a pillow or some form of abnormal weapon.
When you are at that party and that annoying girl in your history class, who you thought was straightedge, comes up to you and pulls a Dirty Down Syndrome which then forces you to strangle her with a giant crayon.
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thumbs down syndrome is a sickness were stupid people like to thumbs down anything and everything if they dont like what they see or read usually a response to internet videos or comments like on youtube that they dont like just to try and prove a point
bob damn bill im not feelin so good i think after readin that latest comment im coming down with thumbs down syndrome it makes me wanna go and lowrate everything that i disagree with maybe that will make me feel better about myself
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