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A severe case of retardation, usually seen in bronies and weeaboos.
Damn, Mike probably has mental cancer from watching all these MLP music videos.
In a nutshell its League of Legends, You just open a game and everyone starts fucking you in your butthole.
Cancer in butthole is my life
person 1: dont be a cancer" person 2: "whats a cancer?" person 1: "Jake Paul"
its basically anyone who says they are Yasuo main but they totally suck at it.
I'm gonna commit suicide, there has been cancer in this match made game.
Cancer is the people that use mei on overwatch
Person 1: hey wanna play overwatch
Person 2: Sure if you don't use mei
Person 1: awwwwe, why she is the best character.
Person 2: Mei is cancer, seriously