When someone is a conplete noob at life, in a really cute/badass way. A knob is not necessarily a bad thing to be called. In fact, people are often very fond of knobs.
Dude 1: Haha, my cousin slipped on a banana peel. I didn't even know that was possible
Dude 2: What a knob!
Plug-ugly geezer who is also being a total git
What an Airy-Fairy Knob that Prat Joey is...
British slang for the male penis.
Bitch come slob on my knob until I bust a nut
"Hey Reece Nichols people say you have a boat knob"
"Oh fuck she said she liked it :("
A good mate who amuses you endlessly but you can't bring yourself to admit it openly is a knob monkey.
Dave, I can't believe you said that, you're a proper knob monkey!