When you have too much fun (read: alcohol) and you're lame the next day and stay in bed and not participate in vacation activities.
In Jamaica, Jim partied too hard and the next day stayed in and was a total puff duff.
Someone that keeps you company outside while you smoke (have a puff).
Greg is such a great puff buddy, he kept me company in the cold last night while I had a smoke.
The act of reading a document or information and passing/sharing it with others
here is the class list, please puff n pass
When you shit 30 tiny pebbles the size of Cocoa Puffs
I’m feeling constipated but all I’m doing is dropping Cocoa Puffs.
going down on a girl. A female blowjob
Yeah i gave her a muff-puff and it was mind blowing.
When you take a hit off a blunt, joint, bong, vape and you blow it into her vagina.
Damn! I totally muff puffe’d that bitch.
The glistening effect of fanny fluid on a proud and luscious beard
Example - Come back up and let me see your muff puff