When you're at a point in life where no matter what you're presented with, it's a come up from the position you're in.
Even though he had just lost both legs in a car wreck, meeting that pregnant chick was a Kelly come up for him
For one to become affected by cannabis.
“If I smoke a joint through my nose, will I still come up dirty?”
“Yes randy, you will still come up dirty.”
A person who was a duff in their past and is now a hot glown up masterpiece
Guy 1: Damn heathers a come up duff!
Guy 2: Yah she used to be really ugly but now I really wanna date her