Slang: To clarify that something is authentic or valid.
That shit is for real, my nigga'
Did you get the new Mary J. Blige CD?
Fo shizzle my nizzo!!!
Reassuring a friend.
-Hey, you sure this where those bitches s'pose to be?
- Fo shizzle my nizzo
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"Hey come see this".....response: "Fo' shizzle my nizzo"