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The reaction to an act of suspicious or most commonly known as "sussy" act.
Ayo, that's a little sus
Having five my little pony figurines shoved up your asshole at the current moment.
Person: Hey Jeffery do you have five my little pony figurines shoved up your ass?
Jeffery: Ayo?!
The perfect response when someone says something that is undisputedly gay
“You want me to suck your toes real quick?
“Ayo??”
It is used to put emphasis on the sentence , with utmost feeling . It may or may not make you look cool. It can also be used to call someone and show surprise, disgust, happiness etc. just by adjusting your tone and expressions.
Ayo do you know what happened yesterday ?
Ayo I'm here bro.
Ayo you got to be kidding me.
Ayo you weren't suppose to snitch like that.
Did you really won the title? Ayo I'm so happy for you bro.
How you respond to a fruity, zesty or gay comment.
iwqjdiowje: Ok now I really gotta fuck you, bring me that ass ghajsdj
ghajsdj: Ayo?!?
When someone says something a little sus
or
when addressing someone.
Person one: I bet that girl has big melons
person two: Ayooooo what did you just say????
or
person one: Ayo where you guyes at, im waiting.