Someone fucking something up because they're incompentent or weren't paying attention, thusly fucking themselves and possibly others over.
Biff: Christy sure dropped the ball on this whole Christmas party thing, now I have to come in this Saturday to help decorate.
Joey: That blows dude, she should be fired.
to try so hard at something, including but not exclusively physical activity, that it seriously hurts you.
"I was tying to lift it but I didn't want to drop a ball doing it."
When talking to someone and you cant think of anything else to say to keep the conversation going
I dropped the ball while talking to lisa the other day.
means to man up and go for it. Get some pluck and smoke a joint, fuck a bitch, anything really.
Okay, Jake, you'll be fine. Why don't you drop your balls and go shit-and-run that house?
God, I wish that kid's balls would drop so we didn't have to hear him screeching all the time.
When a male hits puberty; the balls become saggy when puberty comes, thus they 'drop'
Yo! Did you hear Joe's voice? I guess his balls dropped...
Or
12 Year old squeaker : Hey guys wanna go play some Minecraft on Xbox?
13 Year old Non Squeaker: Shut up dude! Your balls haven't even dropped.
Something that Justin Beiber has yet to experience.
Amber: I love this song!
Amanda: Yeah, this girl has a really great voice.
Amber: That's Justin Beiber.
Amanda: Well maybe one day when his balls drop, nobody will make that mistake.