When you are very very VERY high off of any stimulant, and/or depressant, and/or hallucinogen.
"Yo John how's that Alaskan Thunderfuck?"
"Dude, I'm cooked off my rocker"
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Aussie slang -
To refer to a person that is acting/behaving in a strange or silly way.
"That guy is off his rocker"
"Sam, you are off ya rocker"
"If you act that way, you must be off ya rocker"